With the overuse and abuse of antibiotics & disinfectants in our society at personal level, healthcare facilities and in farming, poultry & animal husbandry, bacteria are getting smarter and devising ways to become drug resistant. There are several bacteria now which are resistant to multiple antibiotics. Infection is a major problem in tertiary care ICUs. Infection may be the primary problem or can happen as an add on to some other disease. Either the disease or the infection can lead to failure of organ systems in the body. When an organ system fails, we have means to support it as and when required. The level of support varies depending on the amount of malfunction.
Simple example is the usage of supplemental oxygen when the
respiratory system is affected, and the lungs are not able to maintain the
oxygen levels in the blood using atmospheric air. The oxygen supplements are given
through simple cannula in the nose or a mask at low flow rate. Depending on the
necessity the flow rate is increased. If this is not sufficient, specialized
masks are used. Next level is administering oxygen at a pressure more than the
atmospheric pressure using machines, which can monitor the pressure levels of
air pumped and avoid damage to lungs due to excessive pressure. Up to this
level of support, patient is conscious and will be breathing on their own. If
masks and increasing the pressure are not sufficient, then a tube is placed
directly into the windpipe of the patient and connected to a ventilator. This
is called invasive ventilation and all the breathing is done by the ventilator.
Patients are generally sedated and paralyzed so that they do not ‘fight’ the
ventilator. New generation ventilators are smart, able to identify patient’s
breathing effort and can supplement, as necessary. All these are done by the
intensive care specialists who have the necessary gadgets and tests to monitor
the patient’s condition continuously.
If the oxygen saturation in the blood is not being
maintained despite the highest level of invasive ventilatory support, the next
available option is called ECMO – extra corporeal membrane oxygenator,
artificial lungs in simple terms. If this also fails, in select patients, lung
transplantation is an option. Simultaneously the original problem of infection
or other systems must also be treated and supported, as necessary. At some
point in time, the patient’s lungs and other systems must improve and start
working again. Otherwise, all these outside supports are of no use. The main
problem is no one can predict accurately whether a particular patient is going
to be benefited for sure or not. When the patient is deteriorating despite the
support given, it is natural tendency to escalate the treatment.
In view of the COVID affecting the lungs primarily, I gave
the example of lung failure. Like this, kidneys, heart, intestines, or liver
may fail and need support. Each support system has increasing levels of
complexity, cost and risk of collateral damage associated with it. Despite the best
will and efforts by experienced doctors, inadvertent injury or complications may
arise during the process of treatment. If this happens, it may worsen patient’s
condition, needs additional treatment and incurs more cost.
Machines used for these supports are reused but, a major
chunk of equipment used these days is discarded after single use to prevent
cross infection. All these cost monies. Whether the patient makes a successful
recovery or not, money must be spent in the effort to save the patient.
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